DSIP

Potential Benefits of DSIP Peptide

• Sleep Regulation: Delta sleep-inducing peptide (DSIP) has been shown in studies to regulate sleep patterns, potentially offering therapeutic benefits for individuals with sleep disorders [1].
• Potential Therapeutic Benefit in Stroke Recovery: A study demonstrated that DSIP peptide might have potential therapeutic benefits in stroke therapy, specifically in accelerating the recovery of motor functions after a stroke [2].
• Anti-Epileptic Effects: Research suggests that the interaction of DSIP with certain drugs, like valproate, can enhance their anti-epileptic effects, potentially providing additional benefits in managing epileptic seizures [3].
• Influence on Electroencephalogram (EEG): DSIP has been observed in research to influence EEG and power spectra in rats, which could potentially be used to study its effects on brain activity and sleep regulation [4].
• Potential Role in Chronic Inflammation: Studies indicates that DSIP peptide may play a role in managing chronic inflammation, particularly in conditions such as end-stage renal disease and dialysis [5].
• Expression and Purification in Pichia pastoris: The yeast Pichia pastoris has been used for the expression of DSIP fusion protein. This approach combines the benefits of Escherichia coli expression (cost-effectiveness and easy scale-up) with the advantages of eukaryotic expression systems, potentially aiding in the large-scale production of DSIP [6].
• Presence in Human Milk: DSIP is one of the bioactive peptides found in human milk, suggesting its potential role in infant nutrition and development [7].

References

[1] https://pubmed.ncbi.nlm.nih.gov/6145137/

[2] https://www.mdpi.com/ 1420-3049/26/17/5173

[3] https://pubmed.ncbi.nlm.nih.gov/17957464/

[4] https://pubmed.ncbi.nlm.nih.gov/11214497/

[5] https://pubmed.ncbi.nlm.nih.gov/30281126/

[6] https://pubmed.ncbi.nlm.nih.gov/28462721/

[7] https://pubmed.ncbi.nlm.nih.gov/3909780/

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